Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase Langkilde A, Kristensen SM, Lo Leggio L, Mølgaard A, Jensen JH, Houk AR, Navarro Poulsen JC, Kauppinen S, Larsen S Acta Crystallogr D Biol Crystallogr 2008 64: 851-63

Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140 Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V and Dalmay T RNA 2008 14: 2513-20

Targeting of microRNAs for therapeutics Stenvang J, Lindow M and Kauppinen S Biochem Soc Trans 2008 36: 1197-2000

SPC3042 - A pro-apoptotic Survivin inhibitor Hansen JB, Fisker N , Westergaard M, Kjærulff LS, Hansen HF, Thrue CA, Rosenbohm C, Wissenbach M, Orum H and Koch T Molecular Cancer Ther 2008 Sep 7 (9): 2736-45

Locked Nucleic Acid holds promise in the treatment of cancer Frieden M and Orum H Current Pharmaceutical Design 2008 14 (11): 1138-42

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/a-secretase expression. Hébert SS , Horré K , Nicolaï L , Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A and Strooper BD Proc Natl Acad Sci USA 2008 105:6415-20

Diagnostic and prognostic microRNAs in stage II colon cancer Schepeler T, Reinert JT, Christensen LL , Silahtaroglu AN, Dyrskjot L, Ostenfeld MS, Wiuf C, Sorensen F J, Kruhoffer M, Laurberg S, Kauppinen S, Orntoft TF and Andersen CL Cancer Res 2008 68:6416-24

An endogenous TNF-a antagonists induced by splice switching oligonucleotides reduces inflammation in arthritis and hepatitis mouse models Graziewicz M , Tarrant T, Buckley B, Roberts J, Fulton L, Hansen H, Orum H, Kole R and Sazani P Mol Ther 2008 16 (7): 1316-22

LNA-mediated microRNA silencing in non-human primates Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M , Hansen HF, Berger U, Gullans S , Kearney P, Sarnow P, Straarup EM and Kauppinen S Nature 2008: 452:896-9

The utility of LNA in microRNA-based cancer diagnostics and therapeutics Stenvang J , Silahtaroglu AN, Lindow M , Elmen J and Kauppinen S Semin Cancer Biol 2008 18: 89-102

MicroRNAs as targets for antisense-based therapeutics Stenvang J and Kauppinen S Exp Opin Biol Ther 2008 8: 59-81

microRNA expression in the adult mouse central nervous system Bak M, Silahtaroglu A, Moller M, Christensen M, Rath MF, Skryabin B, Tommerup N and Kauppinen S RNA 2008 14: 432-44

Locked Nucleic Acid: Properties & therapeutic aspects Koch T, Rosenbohm C, Hansen HF, Hansen JB, Straarup EM and Kauppinen S In: Therapeutic Oligonucleotides 2008 edited by Dr. Jens Kurreck RSC Publishing

Detection and analysis of microRNAs using LNA (Locked Nucleic Acid)-modified probes Kauppinen S In: microRNAs - From Basic Science to Disease Biology, Edited by Krishnarao Appasani. 2008 Cambridge University Press Cambridge

Detection of siRNAs and miRNAs Kauppinen S and Havelda Z Methods Molecular Biology 2008 Vol. 451: 217 -27

Synthesis and biological evaluation of LNA phosphororamidates Jensen J, Sjogren G, Hansen JB, Rosenbohm C and Koch T Nucleosides Nucleotides Nucleic Acids 2008, 27: 37-42

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver Elmen J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjarn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S Nucleic Acids Res 2008 36: 1153-62